5-Bromoisatoic Anhydride → 6-bromoquinazolin-4-ol
반응식
[Br:1][C:2]1[CH:13]=[C:6]2[C:7](O[C:10](=O)[NH:11][C:5]2=[CH:4][CH:3]=1)=[O:8].C([O-])(=O)C.C(N)=[NH2+:19]>CC(O)C>[Br:1][C:2]1[CH:13]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:10][NH:19][C:7]2=[O:8]참가 물질
4
실험 절차
A solution of 5-bromoisatoic anhydride (5.0 g, 21 mmol) and formamidinium acetate (2.2 g, 21 mmol) in 60 mL of i-PrOH was heated at reflux for 10 hours. The reaction mixture was cooled to rt and the white solid was collected by filtration. The white solid was washed with small amount of i-PrOH and dried in air to give desired product 6-bromoquinazolin-4(3H)-one. MS (ESI, pos. ion) m/z: 224.9 (M+1).
후처리
- temperatureat reflux for 10 hours
- filtrationthe white solid was collected by filtration
- washThe white solid was washed with small amount of i-PrOH
- customdried in air
출처 및 근거
- ORD 기록
- ord-638eb79c0919478f92004a860c9e5382
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08198448B2
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