5-Fluoro-7-nitro-1,3-dihydro-indol-2-one → 7-Amino-5-fluoroindolin-2-one

HRID 2191435노트

반응식

HRID 2191435 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-])=O)[CH:10]=1)[NH:7][C:6](=[O:14])[CH2:5]2>C(O)(=O)C.[Pd]>[NH2:11][C:9]1[CH:10]=[C:2]([F:1])[CH:3]=[C:4]2[C:8]=1[NH:7][C:6](=[O:14])[CH2:5]2

참가 물질

4

반응물 1

HCID 592500625-Fluoro-7-nitro-1,3-dihydro-indol-2-one

생성물 1

HCID 592500547-Amino-5-fluoroindolin-2-one수율 97.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

5-Fluoro-7-nitro-1,3-dihydro-indol-2-one 20a (4.0 g, 20 mmol) was dissolved in 200 ml of acetic acid under stirring, and added with palladium on activated carbon (1.0 g, 5%) at room temperature. The reaction system was stirred under a hydrogen atmosphere. After thin lay chromatography showed the disappearance of starting materials, the reaction mixture was filtered, and concentrated under reduced pressure to obtain the title compound 7-amino-5-fluoro-1,3-dihydro-indol-2-one 20b (3.2 g, yield 97.5%) as a white solid.

후처리

  1. stirringThe reaction system was stirred under a hydrogen atmosphere
  2. filtrationthe reaction mixture was filtered
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b6f3c1022aa64b19a2fe88a4783c6c40
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329682B2

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