1,4-Dioxane hydrochloride → 4,4-Dimethyloxolan-3-amine hydrochloride

HRID 2191583노트

반응식

HRID 2191583 반응식
C(OC(=O)[NH:7][CH:8]1[C:12]([CH3:14])([CH3:13])[CH2:11][O:10][CH2:9]1)(C)(C)C.[ClH:16].O1CCOCC1>>[ClH:16].[CH3:13][C:12]1([CH3:14])[CH2:11][O:10][CH2:9][CH:8]1[NH2:7]

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67001595HCID 67001595, 화합물

생성물 1

HCID 670020204,4-Dimethyloxolan-3-amine hydrochloride

실험 절차

(4,4-Dimethyl-tetrahydro-furan-3-yl)-carbamic acid tert-butyl ester (70 mg, 0.32 mmol) was dissolved in 3 mL of cold 4M HCl/dioxane and gradually warmed to room temperature with stirring. After the starting material was judged to be consumed by thin layer chromatography, the reaction mixture was concentrated to afford 4,4-dimethyl-tetrahydro-furan-3-ylamine hydrochloride which was used with further purification.

후처리

  1. customto be consumed by thin layer chromatography
  2. concentrationthe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-c0edaea5c42d4b278c85eb25a68a2bca
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329699B2

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