Trifluoroacetic acid → 4-((E)-3-cyclohexyl-1-propenyl)-2-(4-fluoroanilino)benzoic acid

HRID 2191722노트

반응식

HRID 2191722 반응식
FC(F)(F)C(O)=O.[CH:8]1([CH2:14]/[CH:15]=[CH:16]/[C:17]2[CH:29]=[CH:28][C:20]([C:21]([O:23]C(C)(C)C)=[O:22])=[C:19]([NH:30][C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)[CH:18]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1([CH2:14]/[CH:15]=[CH:16]/[C:17]2[CH:29]=[CH:28][C:20]([C:21]([OH:23])=[O:22])=[C:19]([NH:30][C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)[CH:18]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 68964903tert-butyl 4-((E)-3-cyclohexyl-1-propenyl)-2-(4-fluoroanilino)benzoate

생성물 1

HCID 576677964-((E)-3-cyclohexyl-1-propenyl)-2-(4-fluoroanilino)benzoic acid

실험 절차

Trifluoroacetic acid 15 mL solution of the obtained tert-butyl 4-((E)-3-cyclohexyl-1-propenyl)-2-(4-fluoroanilino)benzoate was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 70-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 4-((E)-3-cyclohexyl-1-propenyl)-2-(4-fluoroanilino)benzoic acid 23 mg of pale yellow solid.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-dc9d497883ee4147a0a9b5ce1b38c7db
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08327467B2

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