CID 6037 → HCID 178484386, 화합물

HRID 2191896노트

반응식

HRID 2191896 반응식
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[CH:10]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:14][CH:13]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:11]=1>C(O)C>[CH:14]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:10][CH:11]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:13]=1.[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3]

참가 물질

4

반응물 2

HCID 6037CID 6037HCID 178484382HCID 178484382, 화합물2회

생성물 1

HCID 178484386HCID 178484386, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매3회

실험 절차

Under nitrogen gas, 150 mL fresh ethanol was added to the free base of metformin in ethanol, and to the free base of metformin in ethanol was slowly added 42 g (0.095 eq.) folacin solid. At that time the temperature of the reaction mixture began to ascend. The reaction was stirred and the adding speed was controlled to keep the reaction temperature not exceeding 50° C. Stirring was continued until the solid was substantially dissolved. When new solid began to present, ⅔-⅘ volume of solvent was removed under reduced pressure, and the reaction was cooled to ambient temperature to give the crude product of folacin-metformin compound.

후처리

  1. customexceeding 50° C
  2. stirringStirring
  3. dissolutionwas substantially dissolved
  4. custom⅔-⅘ volume of solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-ea37497c9b484071a21980134ca89a4a
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329710B2

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