Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → 2-(4,4-Dimethyl-3,4-dihydroquinolin-1(2H)-yl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4,4-Dimethyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 57423310 | — |
| 촉매 | Zinc | HCID 23994 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(4,4-Dimethyl-3,4-dihydroquinolin-1(2H)-yl)aniline | HCID 59337707 | 73% |
반응 단계
The crude 1c (0.66 g) was stirred in MeOH (20 mL) at rt. Solid NH4Cl (0.62 g) was added, followed by addition of Zn dust (3.0 g) portionwise. The resulting mixture was stirred at rt for 2 h. It was filtered through Celite®, rinsed with CH2Cl2, and concentrated to dryness. The residue was purified by flash chromatography (hexanes/EtOAc) to give pure amine 1d (0.43 g, 73% for two steps). LC-MS ESI 253 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08329718B2 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-766cb1a34b974b689e5e6e5f8a63d2f9 |
| 출처 메모 | uspto-grants-2012_12 |