Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl isothiocyanate → 1-benzoyl-3-(2-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)phenyl)thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl isothiocyanate | HCID 68284 | — |
| 반응물 | 2-(4,4-Dimethyl-3,4-dihydroquinolin-1(2H)-yl)aniline | HCID 59337707 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-benzoyl-3-(2-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)phenyl)thiourea | HCID 59337689 | — |
반응 단계
1d (65.4 mg, mmol) and benzoyl isothiocyanate (60 mg) were heated at refluxing CH2Cl2 for 2 h. After cooling, the solvent was evaporated. The resulting crude 1e was dried over vacuum and used directly in the next step: LC-MS ESI, 416.3 (M+H) (10-90% MeOH in H2O with 0.1% TFA in a 4 min run, tR=4.49 min).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08329718B2 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-5ae8c4b4696341a7a6c598b9aec4e23e |
| 출처 메모 | uspto-grants-2012_12 |