Diethyl Ether → HCID 86655279, 화합물

HRID 2192340노트

반응식

HRID 2192340 반응식
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][N:7]=1)=[O:4].[N:13]12[CH2:20][CH2:19][CH:16]([CH2:17][CH2:18]1)[C@@H:15]([O:21][C:22]([C:24]1([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:23])[CH2:14]2.C(OCC)C>C(#N)C>[Cl-:1].[F:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3]([CH2:2][N+:13]23[CH2:20][CH2:19][CH:16]([CH2:17][CH2:18]2)[C@@H:15]([O:21][C:22]([C:24]2([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:23])[CH2:14]3)=[O:4])=[N:7][CH:8]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 229347512-Chloro-N-(5-fluoro-2-pyridinyl)acetamideHCID 591796191-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

생성물 1

HCID 86655279HCID 86655279, 화합물수율 63.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-Chloro-N-(5-fluoro-pyridin-2-yl)-acetamide (Example 17a) (31 mg) was added to a solution of 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (49 mg) in acetonitrile (1 mL). The reaction mixture was stirred at room temperature overnight. Diethyl ether (2 mL) was added to the reaction mixture and the white solid was filtered off, washed several times with diethyl ether and dried under vacuum at 40° C. to give the title compound (49 mg).

후처리

  1. filtrationthe white solid was filtered off
  2. washwashed several times with diethyl ether
  3. customdried under vacuum at 40° C.

출처 및 근거

ORD 기록
ord-801a3f4be019424b827905f4d72f6fe3
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329729B2

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