2-Bromo-N-(3,5-difluorophenyl)acetamide → HCID 53311178, 화합물

HRID 2192360노트

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HRID 2192360 반응식
[Br:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]([F:13])[CH:7]=1)=[O:4].[N:14]12[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]1)[C@@H:16]([O:22][C:23]([C:25]1([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:24])[CH2:15]2>CC#N>[Br-:1].[F:13][C:8]1[CH:7]=[C:6]([NH:5][C:3]([CH2:2][N+:14]23[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]2)[C@@H:16]([O:22][C:23]([C:25]2([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:24])[CH2:15]3)=[O:4])[CH:11]=[C:10]([F:12])[CH:9]=1

참가 물질

4

반응물 2

HCID 231521612-Bromo-N-(3,5-difluorophenyl)acetamideHCID 591796191-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

생성물 1

HCID 53311178HCID 53311178, 화합물수율 17%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 2-bromo-N-(3,5-difluoro-phenyl)-acetamide (42 mg) (Example 35a) and 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (50 mg) in MeCN (1 mL) was stirred at room temperature for 72 h. The solid precipitate was filtered off, washed with ether and dried at 50° C. under vacuum overnight. The mother liquors were evaporated, treated with ether and the resulting solid was filtered off. The solids were combined and crystallised from hot isopropyl alcohol to give the title compound (15 mg) as a colourless solid.

후처리

  1. filtrationThe solid precipitate was filtered off
  2. washwashed with ether
  3. customdried at 50° C. under vacuum overnight
  4. customThe mother liquors were evaporated
  5. additiontreated with ether
  6. filtrationthe resulting solid was filtered off
  7. customcrystallised from hot isopropyl alcohol

출처 및 근거

ORD 기록
ord-40cec1d02a0d40d8958b2d3d407ec4cd
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329729B2

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