N-(3-Bromopropyl)-2-pyridinecarboxamide → HCID 67311727, 화합물

HRID 2192393노트

반응식

HRID 2192393 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10]([C:12]1([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11])[CH2:2]2.[Br:25][CH2:26][CH2:27][CH2:28][NH:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=1)=[O:31]>CC#N>[Br-:25].[C:19]1([C:12]2([C:10]([O:9][C@@H:3]3[CH:4]4[CH2:7][CH2:8][N+:1]([CH2:26][CH2:27][CH2:28][NH:29][C:30]([C:32]5[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=5)=[O:31])([CH2:6][CH2:5]4)[CH2:2]3)=[O:11])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

4

반응물 2

HCID 12983474N-(3-Bromopropyl)-2-pyridinecarboxamideHCID 591796191-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

생성물 1

HCID 67311727HCID 67311727, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (0.31 mmol) and pyridine-2-carboxylic acid (3-bromo-propyl)-amide (Example 57b (0.31 mmol) were stirred together in anhydrous MeCN (3 mL) at room temperature for 16 days. The reaction mixture was concentrated in vacuo and the solid purified by silica gel chromatography eluting with 0-15% MeOH/dichloromethane to give the title compound (145 mg) as a white solid.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe solid purified by silica gel chromatography
  3. washeluting with 0-15% MeOH/dichloromethane

출처 및 근거

ORD 기록
ord-8ef825ce5bf842b1abd58f8579edf26c
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329729B2

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