Hydrogen chloride-ethyl acetate → HCID 68432330, 화합물

HRID 2192786노트

반응식

HRID 2192786 반응식
[NH2:1][C:2]([C@@H:4]1[CH2:9][C@H:8]([N:10]([C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1)=[O:3].C(OCC)(=O)C.[ClH:47]>>[ClH:47].[ClH:47].[NH2:1][C:2]([C@@H:4]1[CH2:5][NH:6][CH2:7][C@H:8]([N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:9]1)=[O:3]

참가 물질

3

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59625490tert-butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate

생성물 1

HCID 68432330HCID 68432330, 화합물

실험 절차

tert-Butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate (230 mg) was dissolved in 1 M hydrogen chloride-ethyl acetate (4 ml), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, ethyl acetate was added and the precipitate was collected by filtration and washed with ethyl acetate to give the object compound (218 mg).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additionethyl acetate was added
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-3ef6f23b6d3d44dabd872fffb81d7810
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329691B2

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