Hydrogen chloride-ethyl acetate → 2-tert-butyl-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-4-[(1,3-oxazol-2-ylmethyl)amino]pyrimidine-5-carboxamide dihydrochloride
반응식
[C:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][C:13]2[O:14][CH:15]=[CH:16][N:17]=2)[C:8]([C:18]([N:20]([CH2:42][CH:43]([CH3:45])[CH3:44])[C@H:21]2[CH2:26][C@@H:25]([C:27]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[O:28])[CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]2)=[O:19])=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].C(OCC)(=O)C.[ClH:52]>>[ClH:52].[ClH:52].[C:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][C:13]2[O:14][CH:15]=[CH:16][N:17]=2)[C:8]([C:18]([N:20]([CH2:42][CH:43]([CH3:45])[CH3:44])[C@H:21]2[CH2:26][C@@H:25]([C:27]([N:29]3[CH2:30][CH2:31][O:32][CH2:33][CH2:34]3)=[O:28])[CH2:24][NH:23][CH2:22]2)=[O:19])=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]참가 물질
3
반응물 2
생성물 1
실험 절차
tert-Butyl (3S,5R)-3-[({2-tert-butyl-4-[(1,3-oxazol-2-ylmethyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (108 mg) was dissolved in 2 M hydrogen chloride-ethyl acetate (2 ml), and the mixture was stirred at room temperature for 16 hr. The reaction mixture was concentrated, ethyl acetate was added and the precipitate was collected by filtration and washed with ethyl acetate to give the object compound (85 mg).