2-Methoxyaniline → 1-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acid

HRID 2193724노트

반응식

HRID 2193724 반응식
[C:1]1([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][O:17]C1C=CC=CC=1N>>[CH3:16][O:17][C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][C:1]=1[NH:7][C:8]([C:10]1([C:13]([OH:15])=[O:14])[CH2:11][CH2:12]1)=[O:9]

참가 물질

3

반응물 2

HCID 70002-MethoxyanilineHCID 190968711-(Phenylcarbamoyl)cyclopropanecarboxylic acid

생성물 1

HCID 550353091-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acid수율 44%

실험 절차

Following the procedure described above for the synthesis of compound 161 (Scheme 45), but replacing aniline for 2-methoxyaniline, title compound 172 was obtained in 44% yield. M/S (m/z): 236.0 (M+H).

출처 및 근거

ORD 기록
ord-7de41b266b4340f09c292de86060d635
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329726B2

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