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4-(Trifluoromethoxy)aniline → 8-(2,2-Dimethyl-propane-1-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194016
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인쇄 미리보기

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HRID 2194016 반응식
C([O:3][C:4]([C:6]1([CH2:20][CH2:21]OC)[CH2:11][CH2:10][N:9]([S:12]([CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])(=[O:14])=[O:13])[CH2:8][CH2:7]1)=O)C.[Cl-].C[Al+]C.[F:28][C:29]([F:39])([F:38])[O:30][C:31]1[CH:37]=[CH:36][C:34]([NH2:35])=[CH:33][CH:32]=1>CCCCCCC>[CH3:18][C:16]([CH3:17])([CH3:19])[CH2:15][S:12]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:3])[N:35]([C:34]3[CH:36]=[CH:37][C:31]([O:30][C:29]([F:38])([F:39])[F:28])=[CH:32][CH:33]=3)[CH2:21][CH2:20]2)[CH2:11][CH2:10]1)(=[O:13])=[O:14]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6008484-(Trifluoromethoxy)anilineHCID 16686359Dimethylalumanylium chlorideHCID 667872401-(2,2-Dimethyl-propane-1-sulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

생성물 1

HCID 498022468-(2,2-Dimethyl-propane-1-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one수율 54.1%

시약·촉매·용매 1

HCID 8900
Heptane
용매

실험 절차

This material was prepared in analogy to example 1 step D) 1-(2,2-dimethyl-propane-1-sulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (0.17 g), dimethylaluminium chloride in heptane (1.0 molar, 1.46 ml) and 4-(trifluoromethoxy)-aniline (0.129 g) to give the desired 8-(2,2-dimethyl-propane-1-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (0.118 g) as an off-white solid. MS (ESI): 449.17 (MH+).

출처 및 근거

ORD 기록
ord-b0d8d47bb80a4c73bcd0a87b99bd43c9
출처 데이터셋
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08329904B2

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