3,3-Dimethylbutanoyl chloride → 8-(3,3-Dimethyl-butyryl)-2-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-2,8-diaza-spiro[4.5]decan-1-one
반응식
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[C:16]([CH2:20][C:21](Cl)=[O:22])([CH3:19])([CH3:18])[CH3:17].[F:24][C:25]([F:36])([F:35])[CH2:26][O:27][C:28]1[N:33]=[CH:32][C:31]([NH2:34])=[CH:30][CH:29]=1>>[CH3:17][C:16]([CH3:19])([CH3:18])[CH2:20][C:21]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:34]([C:31]3[CH:32]=[N:33][C:28]([O:27][CH2:26][C:25]([F:36])([F:24])[F:35])=[CH:29][CH:30]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)=[O:22]참가 물질
4
실험 절차
Brown crystalline solid. MS (ESI): 428.4 (MH+). This example was prepared in analogy to example 7 step A) to B) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), tert-butyl acetyl chloride and 6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine.