1-(4-Iodophenyl)ethan-1-one → 2-(4-Acetyl-phenyl)-8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194134

반응식

HRID 2194134 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[NH:17][CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:10])=[O:9].I[C:23]1[CH:28]=[CH:27][C:26]([C:29](=[O:31])[CH3:30])=[CH:25][CH:24]=1>>[C:29]([C:26]1[CH:27]=[CH:28][C:23]([N:17]2[CH2:16][CH2:15][C:14]3([CH2:20][CH2:21][N:11]([S:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[Cl:1])(=[O:9])=[O:10])[CH2:12][CH2:13]3)[C:18]2=[O:19])=[CH:24][CH:25]=1)(=[O:31])[CH3:30]

참가 물질

3

반응물 2

HCID 728691-(4-Iodophenyl)ethan-1-oneHCID 595779948-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

생성물 1

HCID 595779632-(4-Acetyl-phenyl)-8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

실험 절차

This material was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one and 1-(4-iodo-phenyl)-ethanone. White solid. MS (ESI): 447.1 MH+).

출처 및 근거

ORD 기록
ord-29c4deb313db405095a4cd70cbcf663e
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329904B2

연결된 노트

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