1-(4-Bromophenyl)ethanol → 8-(2-Chloro-benzenesulfonyl)-2-[4-(1-hydroxy-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194136

반응식

HRID 2194136 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[NH:17][CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:10])=[O:9].Br[C:23]1[CH:28]=[CH:27][C:26]([CH:29]([OH:31])[CH3:30])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[N:17]([C:23]3[CH:28]=[CH:27][C:26]([CH:29]([OH:31])[CH3:30])=[CH:25][CH:24]=3)[CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:9])=[O:10]

참가 물질

3

반응물 2

HCID 953521-(4-Bromophenyl)ethanolHCID 595779948-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

생성물 1

HCID 595779828-(2-Chloro-benzenesulfonyl)-2-[4-(1-hydroxy-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

실험 절차

This material was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one and 1-(4-bromo-phenyl)-ethanol. White solid. MS (ESI): 449.1 MH+).

출처 및 근거

ORD 기록
ord-934e8ac9e0d1473d88f4c978c15fb3ca
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329904B2

연결된 노트

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