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Water → HCID 67138479, 화합물

HRID 2194311
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HRID 2194311 반응식
BrC[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:13](=[O:16])([O-])[O-].[K+].[K+].[CH3:19]N(C)C=O.[CH3:24][C:25]1O[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:55]3[CH:54]=[CH:53][CH:52]=[C:51](O)[C:50]=3[C:49]3[C:44]2=[CH:45][CH:46]=[CH:47][CH:48]=3)=[CH:40][C:39]=1[O:59][CH3:60].[OH2:61]>>[CH3:24][C:25]1[O:61][C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][C:49]=3[C:50]3[C:55]2=[CH:54][CH:53]=[CH:52][C:51]=3[O:16][CH2:13][C:11]2[CH:12]=[CH:3][C:4]([C:5]([O:7][CH2:8][CH3:19])=[O:6])=[CH:9][CH:10]=2)=[CH:40][C:39]=1[O:59][CH3:60]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 2734813Methyl 2-(bromomethyl)benzoateHCID 59571732HCID 59571732, 화합물

생성물 1

HCID 67138479HCID 67138479, 화합물

반응 조건

온도
90 °C

실험 절차

47 mg of methyl 2-bromomethylbenzoate and 27 mg of potassium carbonate (powder) were added to N,N-dimethylformamide (2 mL) solution of 98 mg of 9-{4-[(5-methyl-2-phenyloxazole-4-yl)methoxy]-3-methoxybenzyl}-9H-carbazole-4-o 1, and stirred at 90° C. for 1 hour. After the reaction mixture was allowed to cool, water was added thereto, and then extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo, the residue was crystallized from a small amount of ethanol, isolated by filtration with n-hexane, dried under a reduced pressure, and 110 mg of the subject compound was prepared.

후처리

  1. temperatureto cool
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated in vacuo
  7. customthe residue was crystallized from a small amount of ethanol
  8. customisolated by filtration with n-hexane
  9. dry with materialdried under a reduced pressure, and 110 mg of the subject compound
  10. customwas prepared

출처 및 근거

ORD 기록
ord-8cb8cbd342e44d839e2d0839295afb53
출처 데이터셋
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08329913B2

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