Iodoethanol → 4-[4-(3-chloro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1-(2-hydroxy-ethyl)-1H-pyridin-2-one
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:23])[N:13]([C:16]3[CH:21]=[CH:20][NH:19][C:18](=[O:22])[CH:17]=3)[C:14]=2[CH3:15])[CH:5]=[CH:6][CH:7]=1.I[CH2:25][CH2:26][OH:27]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:23])[N:13]([C:16]3[CH:21]=[CH:20][N:19]([CH2:25][CH2:26][OH:27])[C:18](=[O:22])[CH:17]=3)[C:14]=2[CH3:15])[CH:5]=[CH:6][CH:7]=1참가 물질
3
실험 절차
The title compound, white crystalline solid, MS: m/e=368.1, 370.1 (M+H+), was prepared in accordance with the general method of example 3 from 4-[4-(3-chloro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1H-pyridin-2-one and 2-iodoethanol.
출처 및 근거
- ORD 기록
- ord-90584090e7a047b281a0fbd3509b7691
- 출처 데이터셋
- uspto-grants-2012_12