Methanesulfonyl chloride → HCID 178504950, 화합물

HRID 2194575노트

반응식

HRID 2194575 반응식
[NH:1]1[CH2:4][CH:3]([CH2:5][O:6][C:7]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:15][CH:14]=3)=[CH:11][N:10]=[C:9]([NH:25][C@H:26]3[CH2:31][CH2:30][C@@H:29]([CH3:32])[CH2:28][CH2:27]3)[N:8]=2)[CH2:2]1.[CH3:33][S:34](Cl)(=[O:36])=[O:35]>>[CH3:33][S:34]([N:1]1[CH2:2][CH:3]([CH2:5][O:6][C:7]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)=[CH:17][CH:18]=3)=[CH:11][N:10]=[C:9]([NH:25][C@H:26]3[CH2:31][CH2:30][C@@H:29]([CH3:32])[CH2:28][CH2:27]3)[N:8]=2)[CH2:4]1)(=[O:36])=[O:35]

참가 물질

3

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 178461300HCID 178461300, 화합물

생성물 1

HCID 178504950HCID 178504950, 화합물수율 87%

실험 절차

Using the procedure of Example 1 Step 5, 4-((azetidin-3-yl)methoxy)-N-(cis-4-methylcyclohexyl)-5-(4-morpholinophenyl)pyrimidin-2-amine was reacted with methanesulfonyl chloride to provide the title compound in 87% yield. 1H NMR (CDCl3, 400 MHz) 8.09 (s, 1H), 7.34 (d, 2H), 6.93 (d, 2H), 5.17 (sb, 1H), 4.50 (d, 2H), 4.08 (m, 1H), 4.01 (m, 2H), 3.87 (m, 4H), 3.82 (m, 2H), 3.17 (m, 4H), 3.05 (m, 1H), 2.66 (s, 3H), 1.85-1.55 (m, 6H), 1.80-1.40 (m, 3H), 0.94 (d, 3H); MS (ESI) m/z: Calc: 515.3 (M). Found. 516.3 (M+1).

출처 및 근거

ORD 기록
ord-3a6d74b56d1a40d98ecc8f38b1b633ad
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08334292B1

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