Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dibromoethane → 1-[2-(2-Bromo-ethoxy)-5-chloro-4-methoxy-6-methyl-3-(3-phenyl-propoxy)-phenyl]-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dibromoethane | HCID 7839 | — |
| 반응물 | 1-[3-Chloro-6-hydroxy-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-phenyl]-ethanone | HCID 59583518 | — |
| 생성물 | 1-[2-(2-Bromo-ethoxy)-5-chloro-4-methoxy-6-methyl-3-(3-phenyl-propoxy)-phenyl]-ethanone | HCID 59583495 | 100% |
반응 단계
Example 34a (4.3 g, 17 mmol) was reacted with 1,2-dibromoethane (40 mL) as described under General Procedure F to afford the title compound (5.5 g, 100%) as a red oil. 1H NMR (300 MHz, CDCl3) δ 7.33-7.18 (m, 5H), 4.30 (t, J=6.3 Hz, 2H), 4.09 (t, J=6.3 Hz, 2H), 3.89 (s, 3H), 3.51 (t, J=6.0 Hz, 2H), 2.83 (t, J=8.1 Hz, 2H), 2.52 (s, 3H), 2.20 (s, 3H), 2.14-2.05 (m, 2H). MS (ES+) m/z 457 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202513B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-b1410242522548a39c38688c37dfb1a0 |
| 출처 메모 | uspto-grants-2012_06 |