Thiomorpholine → 1-[3-Chloro-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-6-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-ethanone

https://huagongshe.com/reaction/219474

참여 물질

역할	이름	HCID	투입량
반응물	Thiomorpholine	HCID 67164	—
반응물	1-[2-(2-Bromo-ethoxy)-5-chloro-4-methoxy-6-methyl-3-(3-phenyl-propoxy)-phenyl]-ethanone	HCID 59583495	—
생성물	1-[3-Chloro-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-6-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-ethanone	HCID 25254375	79%

반응 조건

온도	65 °C

반응 단계

Example 34b (201 mg, 0.44 mmol) and thiomorpholine were reacted as described under the General Procedure B (except heated to 65° C.) and the crude was purified by flash chromatography (silica-gel, EtOAc/hexane 1:4) yielding the title compound (166 mg, 79%) as an oil. 1H NMR (300 MHz, CDCl3) δ 7.33-7.02 (m, 5H), 4.13-4.06 (m, 4H); 3.88 (s, 3H); 2.82 (dd, J=9.3, 7.5 Hz, 2H); 2.76-2.73 (m, 4H); 2.68-2.64 (m, 6H); 2.52 (s, 3H); 2.20 (s, 3H), 2.13-2.03 (m, 2H). MS (ES+) m/z 478 (M+H+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08202513B2
출처 데이터셋	uspto-grants-2012_06
ORD ID	ord-4e045b7e43ac4e468c690edeaadca965
출처 메모	uspto-grants-2012_06