Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,3-Difluoropyrrolidine hydrochloride → 1-[3-Chloro-6-[2-(3,3-difluoro-pyrrolidin-1-yl)-ethoxy]-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-phenyl]-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,3-Difluoropyrrolidine hydrochloride | HCID 24903482 | — |
| 반응물 | 1-[2-(2-Bromo-ethoxy)-5-chloro-4-methoxy-6-methyl-3-(3-phenyl-propoxy)-phenyl]-ethanone | HCID 59583495 | — |
| 생성물 | 1-[3-Chloro-6-[2-(3,3-difluoro-pyrrolidin-1-yl)-ethoxy]-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-phenyl]-ethanone | HCID 25254374 | 16% |
반응 단계
Example 34b (58 mg, 0.13 mmol) and 3,3-difluoropyrrolidine hydrochloride (2.5 eq.) were reacted as described under General Procedure J and the crude product was purified by flash chromatography (silica gel, hexane/Et2O 70:30) to afford the title compound as a pale yellow oil (10 mg, 16%). 1H NMR (300 MHz, CDCl3) δ 7.33-7.18 (m, 5H), 4.08 (t, J=6.2 Hz, 4H), 3.88 (s, 3H), 2.96 (t, J=13.4 Hz, 2H), 2.85-2.73 (m, 6H), 2.51 (s, 3H), 2.31-2.13 (m, 2H), 2.20-2.04 (m, 2H). MS (ES+) m/z 482.1 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202513B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-82aeb2a80e5244c58bef44690a802cf5 |
| 출처 메모 | uspto-grants-2012_06 |