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Sulfuric Acid → Methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

HRID 2194836
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반응식

HRID 2194836 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](Cl)Cl.OS(O)(=O)=O>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH3:17])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 29126521-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

생성물 1

HCID 2969493Methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid 51 was added 80 mL of CH2Cl2, 30 mL of MeOH, and 1.0 mL of concentrated H2SO4. After heating at reflux overnight, the mixture concentrated and triturated with water to give methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate 52.

후처리

  1. temperatureAfter heating
  2. temperatureat reflux overnight
  3. concentrationthe mixture concentrated
  4. customtriturated with water

출처 및 근거

ORD 기록
ord-2cc664b3ae924667a33cba9c70007ba2
출처 데이터셋
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08334317B2

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