Triacetoxyperiodinane → 1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbaldehyde

HRID 2194844노트

반응식

HRID 2194844 반응식
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[N:10]2)=[CH:5][CH:4]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[N:10]2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 44819037{1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}-methanol

생성물 1

HCID 574169821-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A 100 mL round-bottomed flask was charged with (1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)methanol 64 (0.703 g, 2.90 mmol) and 10 mL CH2Cl2. To this solution was added Dess-Martin periodinane (1.60 g, 3.77 mmol). After stirring at room temperature for 30 min, the reaction was quenched with saturated aqueous sodium thiosulfate. The layers were separated and the organics were dried and concentrated. The concentrate was passed through a short pad of silica gel rinsing with 7:1 hexanes/EtOAc to give 1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbaldehyde 65.

후처리

  1. customthe reaction was quenched with saturated aqueous sodium thiosulfate
  2. customThe layers were separated
  3. customthe organics were dried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-93c130e6b4f146dfa55ac0b0ce0035c5
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08334317B2

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