4-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazine-1-carboxylic acid tert-butyl ester → 4-(4-Fluoro-phenyl)-6-(2-(R)-methyl-piperazin-1-yl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidine

HRID 2195060노트

반응식

HRID 2195060 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[N:17]=[C:16]([N:27]3[CH2:31][CH2:30][CH2:29][C@H:28]3[CH3:32])[N:15]=2)[C@H:10]([CH3:33])[CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[F:26][C:23]1[CH:22]=[CH:21][C:20]([C:18]2[CH:19]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]3[CH3:33])[N:15]=[C:16]([N:27]3[CH2:31][CH2:30][CH2:29][C@H:28]3[CH3:32])[N:17]=2)=[CH:25][CH:24]=1

참가 물질

3

반응물 1

HCID 591682964-[6-(4-Fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 591683354-(4-Fluoro-phenyl)-6-(2-(R)-methyl-piperazin-1-yl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidine

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

Stir 4-[6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazine-1-carboxylic acid tert-butyl ester (4.5 g, 9.88 mmol) in 4M HCl-dioxane (50 mL) for 40 min. Concentrate and partition between EtOAc and sat. NaHCO3. Dry the organic layer (Na2SO4) and concentrate under reduced pressure to yield the title compound.

후처리

  1. concentrationConcentrate
  2. custompartition between EtOAc and sat. NaHCO3
  3. dry with materialDry the organic layer (Na2SO4)
  4. concentrationconcentrate under reduced pressure

출처 및 근거

ORD 기록
ord-c2e7ee63caab4dfb870729ac0dd4f47e
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08334382B2

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