Potassium Carbonate → 4-[4-(5-bromo-3-methyl-pyridin-2-yl)-2-(R)-methyl-piperazin-1-yl]-6-(4-fluoro-phenyl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidine

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH3:29])[C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=4)[N:17]=[C:16](Cl)[N:15]=3)[C@H:10]([CH3:28])[CH2:9]2)=[N:6][CH:7]=1.Br.[CH3:31][C@@H:32]1[CH2:36][CH2:35][CH2:34][NH:33]1.C([O-])([O-])=O.[K+].[K+]>CC(N(C)C)=O>[Br:1][C:2]1[CH:3]=[C:4]([CH3:29])[C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=4)[N:17]=[C:16]([N:33]4[CH2:34][CH2:35][CH2:36][C@H:32]4[CH3:31])[N:15]=3)[C@H:10]([CH3:28])[CH2:9]2)=[N:6][CH:7]=1