Sulfuric Acid → HCID 87551501, 화합물

HRID 219514

반응식

HRID 219514 반응식
[CH:1]1[C:23]2=[C:24]3[C:4]4[C:5]([CH:17]=[CH:18][C:19]3=[C:20](S([O-])(=O)=O)[CH:21]=[C:22]2[OH:25])=[C:6](S([O-])(=O)=O)[CH:7]=[C:8](S([O-])(=O)=O)[C:3]=4[CH:2]=1.[Na+:30].[Na+].[Na+].[S:33](=O)(=[O:36])([OH:35])[OH:34]>>[OH:25][C:22]1[CH:21]=[CH:20][C:19]2[C:24]3=[C:4]4[C:5]([CH:6]=[CH:7][CH:8]=[C:3]4[C:2]([S:33]([O-:36])(=[O:35])=[O:34])=[CH:1][C:23]=13)=[CH:17][CH:18]=2.[Na+:30]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 61388Pyranine

생성물 1

HCID 87551501HCID 87551501, 화합물수율 10%

실험 절차

The synthesis of mono-CysMA is given in Scheme 1. Reaction of HPTS with 30% sulfuric acid at 150° C. for 20 min gave sodium 3-hydroxypyrene-5-sulfonate 1 in 10% yield. Acetylation of 1 followed by chlorination of 2 gave intermediate 3. The polymerizable group was attached via the cysteic acid moiety in compound 4 and reacted with 3 to give compound 5. Chlorosulfonation of 5 was achieved without affecting the polymerizable group and after purification on polystyrene beads gave mono-CysMA in 50% yield over two steps. The dye was characterized by 1H NMR, HPLC, and MS.

후처리

  1. customThe synthesis of mono-CysMA

출처 및 근거

ORD 기록
ord-96bece60c8204dfcbb1479e54b2228c8
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202731B2

연결된 노트

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