2-(4-Nitrophenyl)acetamide → 2-(4-Aminophenyl)acetamide

HRID 219520

반응식

HRID 219520 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([NH2:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([NH2:13])=[O:12])=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 2336132-(4-Nitrophenyl)acetamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 2380342-(4-Aminophenyl)acetamide수율 879.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 4-nitrophenylacetamide 55 (3.2 g, 1.78 mmol) in methanol (50 mL) was added 10% Pd—C (0.32 g) and the resulted mixture was stirred at room temperature for 24 h under 1 atm hydrogen atmosphere. Pd—C was removed by filtration on Celite. The filtered solution was evaporated to provide 55a (2.35 g, 90% yield). 1HNMR (300 MHz, CDCl3-CD3OD): δ 7.06 (d, J=8 Hz, 2H), 6.72 (d, J=8 Hz, 2H), 3.41 (s, 2H).

후처리

  1. customPd—C was removed by filtration on Celite
  2. customThe filtered solution was evaporated

출처 및 근거

ORD 기록
ord-22bb8e8f2dd74fae869245e3f70ca14c
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202843B2

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