Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2-Chloro-2-phenyl-n-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Sulfathiazole | HCID 5340 | — |
| 반응물 | Chloro(phenyl)acetyl chloride | HCID 102902 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Chloro-2-phenyl-n-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide | HCID 57936383 | — |
반응 단계
Synthesized according to general procedure 1: N′-(2-thiazolyl)sulfanilamide (5.60 g, 22 mmol), pyridine (3.6 mL, 44 mmol), 2-chloro-2-phenyl acetylchloride (3.8 mL, 26.4 mmol, 1.2 equiv) in DCM (400 mL). Yield: 6.73 g (75%) of a white solid. 1H-NMR (DMSO-d6) δ 10.85 (s, 1H), 7.78-7.72 (m, 4H), 7.60-7.57 (m, 2H), 7.45-7.37 (m, 3H), 7.25 (d, J=4.6 Hz, 1H), 6.82 (d, J=4.6 Hz, 1H), 5.77 (s, 1H). LC/MS (10-99%) M/Z: M+1 obs=408.1; tR=2.61 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202861B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-e28b7e6f4ec3452ebdef22d257a7808d |
| 출처 메모 | uspto-grants-2012_06 |