Pioglitazone Hydrochloride → Pioglitazone

HRID 2195571노트

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HRID 2195571 반응식
[CH3:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH:19]3[S:25][C:23](=[O:24])[NH:22][C:20]3=[O:21])=[CH:16][CH:17]=2)=[N:7][CH:8]=1.Cl>C(O)(=O)C(C)O.C(O)(=O)CO.CC(C)=O.CO>[CH3:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH:19]3[S:25][C:23](=[O:24])[NH:22][C:20]3=[O:21])=[CH:16][CH:17]=2)=[N:7][CH:8]=1

참가 물질

5

반응물 1

HCID 60560Pioglitazone Hydrochloride

생성물 1

HCID 4829Pioglitazone

시약·촉매·용매 3

HCID 180Acetone용매HCID 887Methanol용매HCID 36797Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)용매

실험 절차

An aqueous solution of 0.5 wt % polyvinyl alcohol (Gosenol EG-05 (registered trademark), manufactured by The Nippon Synthetic Chemical Industry Co., Ltd.) was prepared and used as a poor solvent. In addition, lactic acid-glycolic acid copolymer (PLGA7520, lactic acid/glycolic acid=75/25, weight average molecular weight 20,000, Wako Pure Chemical Industries, Ltd.) (1 g) was dissolved in acetone (40 mL) and mixed with pioglitazone hydrochloride (40 mg) in methanol (20 mL), and the mixture was used as a polymer solution. The solution was added dropwise at 4 mL/min to the earlier-obtained poor solvent at 40° C. with stirring at 400 rpm to give a pioglitazone-containing PLGA nanoparticle suspension. Acetone and methanol were evaporated under reduced pressure for 1.5 hr, and the residue was freeze-dried to give a pioglitazone-containing PLGA nanoparticle powder.

후처리

  1. custom) was prepared
  2. additionThe solution was added dropwise at 4 mL/min to the earlier-obtained poor solvent at 40° C.

출처 및 근거

ORD 기록
ord-e2aa05dda6034318a473f6182cf9c106
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08337896B2

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