Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Quinolinepropionic acid, 1,2,3,4-tetrahydro-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | Dimethyl sulfoxide methanol | HCID 22036561 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Quinolinepropionic acid, 1,2,3,4-tetrahydro- | HCID 98707 | — |
반응 단계
A mixture of the corresponding acid (0.2 mmol), amine (0.2 mmol), triethylamine (28 μL, 0.2 mmol) and HATU (76 mg, 0.2 mmol) in pyridine (0.5 mL) was microwaved at 200° C. for 420 s. The reaction mixture was diluted with 50% DMSO/MeOH (0.5 mL), filtered and purified by HPLC (gradient of 10-99% CH3CN/water).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202861B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-ac3770e1be064b4dbb752ea7ef32733d |
| 출처 메모 | uspto-grants-2012_06 |