Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Ethenyl-4-methylbenzene → 2-ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Ethenyl-4-methylbenzene | HCID 12161 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-ethyl-8-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | HCID 59455066 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole | HCID 57875976 | 9.8% |
반응 단계
The title compound was prepared according to General Method 2. 2-Ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole was prepared from 2-ethyl-2,3,4,5-tetrahydro-8-methyl-1H-pyrido[4,3-b]indole (See Example 6) (100 mg, 0.4 mmol), 4-methylstyrene (1 mL, 7.6 mmol) and NaH (100 mg, 60% dispersion in oil, 2.5 mmol) in DMF (2 ml) at 180° C. for 24 h to obtain 13 mg of 2-ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole after purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08338408B2 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-8f2699c755be4c22ac530004b2166291 |
| 출처 메모 | uspto-grants-2012_12 |