Aminoisobutyric acid → N-(4-{5-[1-(2-fluorophenyl)-5-pyridin-4-yl-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-2-methylalanine

참여 물질

반응 단계

The title compound was prepared following the procedure described for Example 94, but starting from 4-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde, obtained as described in Example 113, Step 1, (200 mg; 0.48 mmol) and 2-amino-2-methylpropanoic acid (100 mg; 0.97 mmol), to give Example 174 as a white solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.76-8.73 (2H, m), 8.00 (2H, d, J=8.1 Hz), 7.94-7.87 (1H, m), 7.77-7.60 (5H, m), 7.55-7.47 (2H, m), 3.96 (2H, s), 1.36 (6H, s). LC/MS (Method C): 498 (M+H)+. HPLC (Method E) Rt 2.35 min (Purity: 98.9%).

출처 및 근거