Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrrolidine → 4-(Pyrrolidin-1-yl)furan-2(5H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | (+-)-3-Methyl-2,4(3H,5H)-furandione | HCID 544553 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(Pyrrolidin-1-yl)furan-2(5H)-one | HCID 13402454 | — |
반응 단계
A mixture of methyl tetronate (2.0 g, 17.5 mmol) and pyrrolidine (4.0 mL, 48 mmol) in EtOH (20 mL) was heated at reflux for 2 hours. The mixture was cooled to room temperature, and evaporated to dryness. The resulting solid was recrystallized with benzene/hexanes to give 4-pyrrolidin-1-ylfuran-2(5H)-one as white crystals. Yield: 2.60 g, 96%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08338415B2 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-e70d9c1bdcc64efcafab5ded3a6d478f |
| 출처 메모 | uspto-grants-2012_12 |