Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → 2-(Pyridin-4-yl)pyrimidine-5-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Methyl 2-(pyridin-4-yl)pyrimidine-5-carboxylate | HCID 69122655 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(Pyridin-4-yl)pyrimidine-5-carboxylic acid | HCID 22710213 | 96% |
반응 단계
A solution of 2-pyridin-4-yl-pyrimidine-5-carboxylic acid methyl ester (1.11 g, 5.18 mmol), and aqueous LiOH (1 M, 5.18 mL) in MeOH (7.25 mL) is stirred at room temperature overnight. MeOH is removed in vacuo, and the aqueous solution is treated with 3 N HCl to adjust the pH to between 2 and 3. The solid is filtered off and washed with water and dried in vacuum to yield 2-pyridin-4-yl-pyrimidine-5-carboxylic acid (1 g, 96%) as a solid. MS: 202 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202863B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-491d2d1456254b5c9f5411093db16779 |
| 출처 메모 | uspto-grants-2012_06 |