Lithium Hydroxide → 2-(Pyridin-4-yl)pyrimidine-5-carboxylic acid

HRID 219639

반응식

HRID 219639 반응식
C[O:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[N:9][CH:10]=1)=[O:4].[Li+].[OH-]>CO>[N:14]1[CH:15]=[CH:16][C:11]([C:8]2[N:7]=[CH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:10][N:9]=2)=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 69122655Methyl 2-(pyridin-4-yl)pyrimidine-5-carboxylate

생성물 1

HCID 227102132-(Pyridin-4-yl)pyrimidine-5-carboxylic acid수율 96%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2-pyridin-4-yl-pyrimidine-5-carboxylic acid methyl ester (1.11 g, 5.18 mmol), and aqueous LiOH (1 M, 5.18 mL) in MeOH (7.25 mL) is stirred at room temperature overnight. MeOH is removed in vacuo, and the aqueous solution is treated with 3 N HCl to adjust the pH to between 2 and 3. The solid is filtered off and washed with water and dried in vacuum to yield 2-pyridin-4-yl-pyrimidine-5-carboxylic acid (1 g, 96%) as a solid. MS: 202 (M+H).

후처리

  1. customMeOH is removed in vacuo
  2. additionthe aqueous solution is treated with 3 N HCl
  3. filtrationThe solid is filtered off
  4. washwashed with water
  5. customdried in vacuum

출처 및 근거

ORD 기록
ord-491d2d1456254b5c9f5411093db16779
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202863B2

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