Di-tert-butyl 1-(5-formylthiophen-2-yl)hydrazine-1,2-dicarboxylate → Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylate

HRID 2196509노트

반응식

HRID 2196509 반응식
[C:1]([C:3]1[S:7][CH:6]=[C:5](N(C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[CH:4]=1)#[N:2].C(C1SC([N:31]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=CC=1)=O>>[C:1]([C:3]1[S:7][C:6]([N:31]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[NH:32][C:33]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:34])=[CH:5][CH:4]=1)#[N:2]

참가 물질

3

반응물 2

HCID 59843212Di-tert-butyl 1-(5-formylthiophen-2-yl)hydrazine-1,2-dicarboxylateHCID 59843278Di-tert-butyl 1-(5-cyanothiophen-3-yl)hydrazine-1,2-dicarboxylate

생성물 1

HCID 59843233Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylate수율 75%

실험 절차

Following the same procedure as described for compound 12 (step 2, scheme 2, example 1c) except using 19 (935 mg, 2.73 mmol) instead of 11 to provide compound 20 (692 mg, 75%) as a yellow solid. LRMS (ESI): calc. 339.1; found 340.2 (MH)+.

출처 및 근거

ORD 기록
ord-e891dd38a3ce451e965553d98f67a34a
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338437B2

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