4-(5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)thiophene-2-carbonitrile → HCID 59843210, 화합물

HRID 2196511노트

반응식

HRID 2196511 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1N(C2C=C(C#N)SC=2)N=[C:8]([C:18]([F:21])([F:20])[F:19])[CH:7]=1.[Cl-].[C:23]([C:25]1[S:29][C:28]([NH2+:30][NH2:31])=[CH:27][CH:26]=1)#[N:24]>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:30]([C:28]2[S:29][C:25]([C:23]#[N:24])=[CH:26][CH:27]=2)[N:31]=[C:8]([C:18]([F:19])([F:20])[F:21])[CH:7]=1

참가 물질

3

반응물 2

HCID 598432044-(5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)thiophene-2-carbonitrileHCID 69090430HCID 69090430, 화합물

생성물 1

HCID 59843210HCID 59843210, 화합물수율 37%

실험 절차

Following the same procedure as described for compound 14 (step 4, scheme 2, example 1c) except using 21 (278 mg, 1.58 mmol) instead of 13 to afford 22 (182 mg, 37%) as a beige solid. LRMS (ESI): calc. 309.1; found 310.1 (MH)+.

출처 및 근거

ORD 기록
ord-319d1fe9e0a847b9bce8789647a30ce8
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338437B2

반응 노트

불러오는 중…