1-(1-Naphthalen-1-yl-ethyl)-aziridine-2-carboxylic acid but-3-enyl-phenethyl-amide → 1-(1-Naphthalen-1-yl-ethyl)-6-phenethyl-octahydro-pyrrolo[2,3-c]pyridin-7-one

HRID 2196830

반응식

HRID 2196830 반응식
[CH2:1]([N:5]([CH2:23][CH2:24]C1C=CC=CC=1)[C:6]([CH:8]1[CH2:10][N:9]1[CH:11]([C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:12])=[O:7])[CH2:2][CH:3]=[CH2:4]>ClC1C=CC=CC=1Cl>[C:13]1([CH:11]([N:9]2[CH:8]3[C:6](=[O:7])[N:5]([CH2:23][CH2:24][C:13]4[CH:22]=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH2:1][CH2:2][CH:3]3[CH2:4][CH2:10]2)[CH3:12])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1

참가 물질

3

반응물 1

HCID 866010821-(1-Naphthalen-1-yl-ethyl)-aziridine-2-carboxylic acid but-3-enyl-phenethyl-amide

생성물 1

HCID 670032651-(1-Naphthalen-1-yl-ethyl)-6-phenethyl-octahydro-pyrrolo[2,3-c]pyridin-7-one수율 42.7%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

실험 절차

A solution of 3 (15 g, 58.7 mmol) in o-dichlorobenzene (100 mL) is heated at 250° C. for 1200 s in a microwave reactor. The mixture is purified by flash chromatography (silica gel; Hexane/EtOAc 1:1; second spot) to provide 5 g (33%) of the title compound as an enantiomerically pure compound. M+H+=399.32.

후처리

  1. customThe mixture is purified by flash chromatography (silica gel; Hexane/EtOAc 1:1; second spot)

출처 및 근거

ORD 기록
ord-504e134a883340c6bfdbe72bd36675b8
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338440B2

연결된 노트

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