Water → 3-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one

HRID 2197434노트

반응식

HRID 2197434 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2(O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH2:19]CC.[NH3:23].C(O)C.O>C(Cl)Cl>[NH2:23][C:5]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=2)[NH:7][C:6]1=[O:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 22020343Ethanol, reaction products with ammonia, distn. residuesHCID 574664415-Chloro-3-hydroxy-3-(2-propoxyphenyl)-indole-2-one

생성물 1

HCID 219254143-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

10 g (32.45 mmol) of the intermediate product 2a were suspended in 100 ml methylene chloride. After the addition of 100 ml 2-molar ethanol ammonia solution, the reaction mixture was stirred for 16 h. After this, everything was poured on to icy water and the organic phase was separated. The aqueous phase was cooled, wherein a white crystallizate formed, which was isolated. 5.7 g of the product were obtained.

후처리

  1. customthe organic phase was separated
  2. temperatureThe aqueous phase was cooled, wherein a white crystallizate
  3. customformed
  4. customwhich was isolated

출처 및 근거

ORD 기록
ord-415ab69707b646358d578f706e879008
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338590B2

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