Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-nitrobutyrate → 8-Benzyloxy-5-hydroxy-4-nitrooctanoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-nitrobutyrate | HCID 25604 | — |
| 반응물 | 4-Benzyloxybutanal | HCID 231559 | — |
| 반응물 | Sparteine | HCID 644020 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 8-Benzyloxy-5-hydroxy-4-nitrooctanoic acid methyl ester | HCID 59336227 | — |
반응 단계
4-benzyloxybutanal (1.463 g, 8.2 mmol), methyl-4-nitrobutyrate (1.29 g, 8.8 mmol) and (−)-sparteine (206 mg, 0.88 mmol) are combined and stirred at RT for 6 hours. EtOAc (5 mL) is added, and the solution is filtered through silica. The solvent is removed in vacuo to yield a pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08338620B2 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-9d4ca1a4aa13472e813b368569984535 |
| 출처 메모 | uspto-grants-2012_12 |