참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl-4-(1-carbamoylpropylamino)butyrate | HCID 9877677 | — |
| 반응물 | HCID 178516071 | HCID 178516071 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Levetiracetam | HCID 5284583 | — |
반응 단계
Hydrochloride salt of methyl-4-(1-carbamoylpropylamino)butyrate (VId) (0.7 g, 2.9 mmol) is dissolved in a mixture of tetrahydrofuran (10 ml) and triethylamine (0.6 g, 2 equiv.). The suspension is filtered and filtrates are concentrated to dryness to afford an oil. The resulting residue is dissolved in toluene (15 ml) and 2-hydroxypyridine (53 mg, 0.56 mmol, 20 mol %) is added. The mixture is heated to 80° C. until complete conversion. After 3 days (GC: 100% conversion) the mixture is concentrated to dryness under reduced pressure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08338621B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_12 |
|---|
| ORD ID | ord-b8a1de58066b4f37819224912b810818 |
|---|
| 출처 메모 | uspto-grants-2012_12 |
|---|
