참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate | HCID 83264 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-Ethylpyridin-2-amine | HCID 89021 | — |
반응 단계
The product from Example 1a (4.93 g, 0.025 mol) was dissolved in a mixture of EtOH (80 mL) and water (30 mL). To this was added hydroxylamine hydrochloride (8.6 g, 0.123 mol) and the resulting mixture heated to 100° C. for 8 h. The reaction mixture was poured into dilute sodium hydroxide solution and the crude product isolated by extraction with CH2Cl2 and dried over MgSO4 filtered and concentrated under vacuum giving the title compound. The material was used as isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08338605B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_12 |
|---|
| ORD ID | ord-1e80fa44fa2048f6874f4c4088eb0c94 |
|---|
| 출처 메모 | uspto-grants-2012_12 |
|---|
