4-Methyl-2-nitroaniline → 2-Bromo-4-methyl-6-nitroaniline

HRID 2197940노트

반응식

HRID 2197940 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[Br:12]Br>CC(O)=O.O>[Br:12][C:6]1[CH:7]=[C:2]([CH3:1])[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]=1[NH2:8]

참가 물질

5

반응물 2

HCID 69784-Methyl-2-nitroanilineHCID 24408Bromine

생성물 1

HCID 27753062-Bromo-4-methyl-6-nitroaniline

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

The title compound was prepared by dissolving 4-Methyl-2-nitro-phenylamine (20.0 g, 131 mmol) in 200 mL of HOAc. The reaction mixture was then heated to 100° C. until reaction mixture was homogeneous. At this point the reaction mixture was cooled to room temperature and Br2 (25.21 g, 157 mmol) was added drop wise over the course of 10 minutes. An orange solid formed, and upon completion of the addition the reaction mixture was diluted with water and the title compound collected by filtration (29 g, 96%).

후처리

  1. temperatureAt this point the reaction mixture was cooled to room temperature
  2. customAn orange solid formed
  3. additionupon completion of the addition the reaction mixture
  4. filtrationthe title compound collected by filtration (29 g, 96%)

출처 및 근거

ORD 기록
ord-21b61d21af0c42aeae25fad031b4b819
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338605B2

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