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4-Chloro-3-nitrotoluene → 3-(4-Methyl-2-nitro-phenylsulfanyl)-phenylamine

HRID 2197957
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HRID 2197957 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([SH:8])[CH:5]=[CH:6][CH:7]=1.Cl[C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[N+:17]([O-:19])=[O:18].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[CH3:16][C:13]1[CH:14]=[CH:15][C:10]([S:8][C:4]2[CH:3]=[C:2]([NH2:1])[CH:7]=[CH:6][CH:5]=2)=[C:11]([N+:17]([O-:19])=[O:18])[CH:12]=1
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참가 물질

6

반응물 3

HCID 69764-Chloro-3-nitrotolueneHCID 11430Potassium CarbonateHCID 315773-Aminothiophenol

생성물 1

HCID 684579173-(4-Methyl-2-nitro-phenylsulfanyl)-phenylamine수율 33%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

The title compound was prepared from 3-Amino-benzenethiol (5.034 g, 40.21 mmol), 1-Chloro-4-methyl-2-nitro-benzene (4.600 g, 26.81 mmol) and K2CO3 (6.484 g, 46.92 mmol) dissolved in DMF and heated to 100° C. for 16 hrs. At this time the reaction mixture was cooled to room temperature and diluted with water, extracted with ethyl acetate. Dried over Na2SO4, filtered and concentrated under vacuum giving the title compound (2.3 g, 32%).

후처리

  1. temperatureAt this time the reaction mixture was cooled to room temperature
  2. extractionextracted with ethyl acetate
  3. dry with materialDried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-82e0ea37af804560abe394a97d72b584
출처 데이터셋
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08338605B2

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