5-Chloro-2-methyl-1,8-naphthyridine → HCID 68459144, 화합물

HRID 2197971

반응식

HRID 2197971 반응식
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:12])=[N:7]2.[CH3:13][O:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:19]([NH2:29])[CH:18]=1)=[O:16]>>[CH3:13][O:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)=[C:19]([NH:29][C:2]2[C:3]3[C:8](=[N:7][C:6]([CH3:12])=[CH:5][CH:4]=3)[N:9]=[CH:10][CH:11]=2)[CH:18]=1)=[O:16]

참가 물질

3

반응물 2

HCID 122663725-Chloro-2-methyl-1,8-naphthyridineHCID 67497797Methyl 2-amino-[1,1'-biphenyl]-4-carboxylate

생성물 1

HCID 68459144HCID 68459144, 화합물

실험 절차

The product from Example 1d (0.0552 g, 0.309 mmol) was reacted with the product from Example 212c (0.070 g, 0.309 mmol) for 92 h following the procedure of Example 1g giving the crude title compound, which was purified by HPLC with AA. The resulting solid was triturated with 4N HCl in dioxane to generate the hydrochloride salt which was collected by vacuum filtration (0.0747 g, 55%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.72 (s, 3H) 3.91 (s, 3H) 6.27 (d, J=6.99 Hz, 1H) 7.30 (m, J=6.99 Hz, 3H) 7.52 (m, 2H) 7.74 (d, J=8.82 Hz, 1H) 7.79 (d, J=8.09 Hz, 1H) 8.09 (d, J=1.47 Hz, 1H) 8.16 (dd, J=7.91, 1.65 Hz, 1H) 8.30 (d, J=6.99 Hz, 1H) 9.15 (d, J=8.82 Hz, 1H) 11.54 (s, 1H); MS (ESI+) m/z 369.9 (M+H)+.

출처 및 근거

ORD 기록
ord-7dcbde1c82fc4f4b9a8c4ee29258f93a
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338605B2

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