Benzyl Bromide → N-[4-(2-Amino-4-benzyloxy-phenylsulfanyl)-phenyl]-acetamide

HRID 2198003노트

반응식

HRID 2198003 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=1.[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 67250701N-[4-(2-Amino-4-hydroxy-phenylsulfanyl)-phenyl]-acetamide

생성물 1

HCID 68460688N-[4-(2-Amino-4-benzyloxy-phenylsulfanyl)-phenyl]-acetamide수율 100.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of the product from Example 232b (56 mg, 0.17 mmol), benzyl bromide (21 mg, 0.17 mmol) and potassium carbonate (26 mg, 0.19 mmol) in DMF (1 mL) was stirred at room temperature 15 hr. The next day, the reaction mixture was poured onto ice and the solid collected by filtration providing the title compound (62 mg, 100%).

후처리

  1. additionThe next day, the reaction mixture was poured onto ice
  2. filtrationthe solid collected by filtration

출처 및 근거

ORD 기록
ord-23375edf9dc743a1a9030c299c57d41d
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338605B2

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