4-Hydroxypyrrolidine → 1-[3-Fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol
반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([F:12])([F:11])[F:10].[OH:13][CH:14]1[CH2:18][CH2:17][NH:16][CH2:15]1>>[F:8][C:4]1[C:3]([C:9]([F:12])([F:11])[F:10])=[C:2]([N:16]2[CH2:17][CH2:18][CH:14]([OH:13])[CH2:15]2)[CH:7]=[CH:6][CH:5]=1참가 물질
3
실험 절차
The title compound (6.2 g, yield 24%) was obtained from 1-bromo-3-fluoro-2-(trifluoromethyl)benzene and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.
출처 및 근거
- ORD 기록
- ord-b57590e32b9e42eaad5d61f2b2c47f96
- 출처 데이터셋
- uspto-grants-2012_12
- 특허 번호
- US08338622B2
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