Dichloromethane → Diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride
반응식
C(OC([NH:8][CH:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([C:33]([OH:35])=[O:34])[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)(C)(C)C.C(Cl)[Cl:37]>>[ClH:37].[NH2:8][CH:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([C:33]([OH:35])=[O:34])[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]참가 물질
3
실험 절차
Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate (3.98 g, 8.40 mmol) is dissolved in methylene chloride (150.0 mL), and hydrogen chloride gas is bubbled through the solution for 15 minutes. The sealed reaction is stirred for 2.5 hours, and then the solvent is evaporated to give diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride.
후처리
- customhydrogen chloride gas is bubbled through the solution for 15 minutes
- customThe sealed reaction
- customthe solvent is evaporated